An orally available TLR7 agonist (EC50 = 291 nM); stimulates a TLR7 immune response in two different animal models of chronic HBV infection and inhibits HIV-1 infection in human peripheral blood mononuclear cells

GS-9620 – 10 mg

Brand:
Cayman
CAS:
1228585-88-3
Storage:
-20
UN-No:
Non-Hazardous - /

GS-9620 is an orally available agonist of toll-like receptor 7 (TLR7; EC50 = 291 nM) with 30-fold selectivity over TLR8 (EC50 = 9 µM).{32637} It has been shown to stimulate a TLR7 immune response in two different animal models of chronic hepatitis B infection and to inhibit HIV-1 infection in human peripheral blood mononuclear cells.{32636,32635,32634}  

 

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Description

An orally available TLR7 agonist (EC50 = 291 nM); stimulates a TLR7 immune response in two different animal models of chronic HBV infection and inhibits HIV-1 infection in human peripheral blood mononuclear cells

Formal name: 4-amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone

Synonyms:  Vesatolimod

Molecular weight: 410.5

CAS: 1228585-88-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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