A caspase-independent (nonapoptotic) cell death inducer; inhibits FLT3 (IC50 = 0.34 µM) and DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 µM

7BIO – 50 mg

Brand:
Cayman
CAS:
916440-85-2
Storage:
-20
UN-No:
Non-Hazardous - /

7BIO is a derivative of indirubin (Item No. 14155) that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation.{31285} Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3.{31285,22470} Instead, 7BIO inhibits FLT3 (IC50 = 0.34 µM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 µM, respectively).{31285,31284} It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 µM, respectively.{31285,31283}  

 

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Description

A caspase-independent (nonapoptotic) cell death inducer; inhibits FLT3 (IC50 = 0.34 µM) and DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 µM, respectively); also inhibits Aurora B and C kinases (IC50s = 4.6 and 0.7 µM, respectively)

Formal name: 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Synonyms:  7-Bromoindirubin-3’-oxime

Molecular weight: 356.2

CAS: 916440-85-2

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Death||Research Area|Cell Biology|Cell Signaling

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