A natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells

Swinholide A – 50 µg

Brand:
Cayman
CAS:
95927-67-6
Storage:
-20
UN-No:
Non-Hazardous - /

Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.{31286,31287} It stabilizes actin dimers and also binds to and severs F-actin filaments.{31286,31288} Swinholide A binds to G-actin in a 1:2 molar ratio and decreases the rate of nucleotide exchange in G-actin.{31287}  

 

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Description

A natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells

Formal name: (1R,3S,5E,7E,11S,12S,13R,15S,16S,17S,19S,23R,25S,27E,29E,33S,34S,35R,37S,38S,39S,41S)-3,13,15,25,35,37-hexahydroxy-11,33-bis[(1S,2S,3S)-2-hydroxy-1,3-dimethyl-5-[(2S,4R,6S)-tetrahydro-4-methoxy-6-methyl-2H-pyran-2-yl]pentyl]-17,39-dimethoxy-6,12,16,28,34,38-hexamethyl-10,32,45,46-tetraoxatricyclo[39.3.1.119,23]hexatetraconta-5,7,21,27,29,43-hexaene-9,31-dione

Synonyms: 

Molecular weight: 1,389.90

CAS: 95927-67-6

Purity: ≥97%

Formulation: An oil

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Toxins||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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