A naturally derived macrolide that inhibits actin polymerization in vitro at 5-10 µg/ml; demonstrates cytotoxic activity in mouse KA31T and NIH3T3 tumor cells (GI50s = 1 and 4 µg/ml

16-epi Latrunculin B – 100 µg

Brand:
Cayman
CAS:
444911-05-1
Storage:
-20
UN-No:
Non-Hazardous - /

16-epi Latrunculin B, first isolated from the Red Sea sponge N. magnifica, is a stereoisomer of the actin polymerization inhibitor, latrunculin B (Item No. 10010631).{31273,31274} At 5-10 µg/ml, 16-epi latrunculin B can disrupt microfilament activity in an actin disruption assay.{31274} It also demonstrates cytotoxic activity in mouse KA31T and NIH3T3 tumor cells (GI50s = 1 and 4 µg/ml, respectively) and antiviral activity against herpes simplex type 1 virus (ED50 = 1 µg/ml).{31273}  

 

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Description

A naturally derived macrolide that inhibits actin polymerization in vitro at 5-10 µg/ml; demonstrates cytotoxic activity in mouse KA31T and NIH3T3 tumor cells (GI50s = 1 and 4 µg/ml, respectively) and antiviral activity against HSV-1 (ED50 = 1 µg/ml)

Formal name: (4S)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone

Synonyms: 

Molecular weight: 395.5

CAS: 444911-05-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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