An inhibitor of PDE1 that has diverse cerebral and neurological effects in vivo; also directly inhibits IKKβ (IC50 = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo

Vinpocetine – 50 mg

Brand:
Cayman
CAS:
42971-09-5
Storage:
-20
UN-No:
Non-Hazardous - /

Vinpocetine is a semi-synthetic alkaloid commonly used as an inhibitor of phosphodiesterase 1 (PDE1), blocking the hydrolysis of both cAMP and cGMP (Ki = 14 µM).{31354,31355} In addition to its use as a selective PDE1 inhibitor in basic research, vinpocetine has diverse cerebral and neurological effects in vivo.{31355} Vinpocetine also directly inhibits the kinase activity of IKKβ (IC50 = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo.{31353}  

 

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Description

An inhibitor of PDE1 that has diverse cerebral and neurological effects in vivo; also directly inhibits IKKβ (IC50 = 17 µM in a cell-free system) and blocks TNF-α- and LPS-mediated activation of NF-κB in cells and in vivo

Formal name: (3α,16α)-eburnamenine-14-carboxylic acid, ethyl ester

Synonyms:  Apovincaminic Acid ethyl ester|AY 27255|RGH-4405

Molecular weight: 350.5

CAS: 42971-09-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Immunology & Inflammation||Research Area|Neuroscience

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