A control analog of the GSK3α/β inhibitor

MeBIO – 5 mg

Brand:
Cayman
CAS:
667463-95-8
Storage:
-20
UN-No:
Non-Hazardous - /

MeBIO is a control analog of the GSK3α/β inhibitor, BIO (Item No. 13123). It displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively).{17161,17160} MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.{31223}  

 

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Description

A control analog of the GSK3α/β inhibitor, BIO; displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively); AhR agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively)

Formal name: (3Z)-6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-1-methyl-2H-indol-2-one

Synonyms:  1-Methyl-6-bromo-indirubin-3’-oxime|Me6BIO

Molecular weight: 370.2

CAS: 667463-95-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area

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