A mixture of ganglioside GD1b with C18:1 and C20:1 fatty acyl chains; a component of plasma membranes; packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events; the concentration of ganglioside GD1b in human brain increases with age; levels are positively correlated with pilocytic astrocytoma tumor grade

Ganglioside GD1b Mixture (sodium salt) – 1 mg

Brand:
Cayman
CAS:
19553-76-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events.{31218} The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects.{31219} Ganglioside GD1b levels are positively correlated with pilocytic astrocytoma tumor grade, and GD1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas.{54530} Ganglioside GD1b mixture contains ganglioside GD1b molecular species with C18:1 and C20:1 fatty acyl chains.  

 

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Description

A mixture of ganglioside GD1b with C18:1 and C20:1 fatty acyl chains; a component of plasma membranes; packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events; the concentration of ganglioside GD1b in human brain increases with age; levels are positively correlated with pilocytic astrocytoma tumor grade

Formal name:

Synonyms:  Disialoganglioside GD1b Mixture|Ganglioside C1 Mixture|Ganglioside G2 Mixture

Molecular weight: 1,882.10

CAS: 19553-76-5

Purity: ≥98%

Formulation: A lyophilized powder

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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