A selective

Cobimetinib – 5 mg

Brand:
Cayman
CAS:
934660-93-2
Storage:
-20
UN-No:
Non-Hazardous - 3077 / 9

Cobimetinib is a potent, orally available inhibitor of MEK1 (IC50 = 4.2 nM).{27940,32043} It shows more than 100-fold selectivity for MEK when tested against a panel of more than 100 serine-threonine and tyrosine kinases. Cobimetinib induces differentiation and apoptosis in cancer cell lines and is more effective when combined with additional inhibitors, like PLX4032 (Item No. 10618).{32043,32044,32045}  

 

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Description

A selective, orally available inhibitor of MEK1 (IC50 = 4.2 nM); induces differentiation and apoptosis in cancer cells lines

Formal name: [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl]-methanone

Synonyms:  GDC-0973|RG-7420|XL518

Molecular weight: 531.3

CAS: 934660-93-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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