A bioactive sphingolipid; the primary short-chain ceramide found in brain tissue; synthesis is regulated by Lass1 in mice; positively correlated to body mass index and inversely related to insulin sensitivity; reduces cell growth in UM-SCC-22A squamous cell carcinoma cells; selectively downregulated in 32 squamous cell carcinoma tumor tissues; positively correlated to body mass index and inversely related to insulin sensitivity in type 2 diabetic patients

C18 Ceramide (d18:1/18:0) – 5 mg

Brand:
Cayman
CAS:
2304-81-6
Storage:
-20
UN-No:
Non-Hazardous - /

C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030}  

 

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Description

A bioactive sphingolipid; the primary short-chain ceramide found in brain tissue; synthesis is regulated by Lass1 in mice; positively correlated to body mass index and inversely related to insulin sensitivity; reduces cell growth in UM-SCC-22A squamous cell carcinoma cells; selectively downregulated in 32 squamous cell carcinoma tumor tissues; positively correlated to body mass index and inversely related to insulin sensitivity in type 2 diabetic patients

Formal name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octadecanamide

Synonyms:  Cer(d18:1/18:0)|Ceramide (d18:1/18:0)|N-Stearoyl-D-Sphingosine

Molecular weight: 566

CAS: 2304-81-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Lipid Biochemistry|Sphingolipids

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