An antagonist of CBX7 that acts by binding the CBX7 chromodomain; induces transcriptional derepression of CBX7 target genes

MS351 – 5 mg

Brand:
Cayman
CAS:
472984-79-5
Storage:
-20
UN-No:
Non-Hazardous - /

MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.{33591} It enhances the binding of long noncoding RNA to the CBX7 chromodomain when used at 25 µM.{33591} MS351 induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells.{33591}  

 

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Description

An antagonist of CBX7 that acts by binding the CBX7 chromodomain; induces transcriptional derepression of CBX7 target genes, including p16 (INK4a), in mouse embryonic stem cells and human prostate cancer PC3 cells

Formal name: α-(3,4-dichlorophenyl)-2,3-dihydro-2-imino-3-[(2-methylphenyl)methyl]-1H-benzimidazole-1-ethanol, monohydrochloride

Synonyms: 

Molecular weight: 462.8

CAS: 472984-79-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Cell Biology|Stem Cell Research||Research Area|Epigenetics, Transcription, & Translation|Readers|Chromodomains

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