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Pertussis Toxin (islet-activating protein) – 50 µg

Brand:
Cayman
CAS:
70323-44-3
Storage:
2-8
UN-No:
Non-Hazardous - 3462 / 6.1

Pertussis toxin (islet-activating protein) is a toxin, first isolated from B. pertussis, that is used to study G protein-coupled receptor signaling in cells and experimental autoimmune encephalomyelitis (EAE) in animals. Pertussis toxin catalyzes the transfer of the ADP-ribose moiety of NAD to the α subunits of heterotrimeric Gi/o proteins, resulting in the receptors being uncoupled from Gi/o proteins.{31502,31505} Pertussis toxin is also used as an adjuvant, given with specific antigens, to immunize animals and induce EAE, an animal model of multiple sclerosis.{31501,31504} Pertussis toxin was first described as an islet-activating protein because it caused a sustained potentiation of the secretory response of pancreatic islet cells to various stimuli that stimulate Gi-linked α-adrenergic receptors.{31500,31503}  

 

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Description

A toxin that is used to study Gi/o-linked GPCR signaling in cells and EAE in animals; completely blocks the ability of AC to be inhibited by GPCRs that signal through Gi subunits

Formal name:

Synonyms: 

Molecular weight: 0

CAS: 70323-44-3

Purity: ≥95% (estimated by SDS-PAGE)

Formulation: Each vial, when reconstituted to 500 μl with water, contains 50 μg of pertussis toxin in 0.03 M sodium phosphate, 0.05 M sodium chloride, pH 7.0

Product Type|Proteins||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Neuroscience

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