An inhibitor of adenylosuccinate synthase (mean IC50 = 4.8 μM and 10 μM in T-ALL and CAK-1 cells

L-Alanosine – 10 mg

Brand:
Cayman
CAS:
5854-93-3
Storage:
-20
UN-No:
Non-Hazardous - /

L-Alanosine is an antibiotic derived from bacterium S. alanosinicus with antineoplastic activity in cells deficient in methylthioadenosine phosphorylase (MTAP) (mean IC50 = 4.8 μM and 10 μM in T-ALL and CAK-1 cells, respectively).{34433,34434} L-Alanosine inhibits adenylosuccinate synthetase to disrupt de novo purine biosynthesis, inhibiting cellular metabolism in MTAP-deficient tumor cells.{34435,34436,34437}  

 

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Description

An inhibitor of adenylosuccinate synthase (mean IC50 = 4.8 μM and 10 μM in T-ALL and CAK-1 cells, respectively); antineoplastic activity in MTAP deficient cells; disrupts de novo purine biosynthesis and inhibits cellular metabolism

Formal name: 3-(hydroxynitrosoamino)-L-alanine

Synonyms:  NSC 153353|NSC 529469|SDX-102

Molecular weight: 149.1

CAS: 5854-93-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Metabolism

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