A pyrimidine dicarboxamide that selectively inhibits MMP-13 (IC50 = 8 nM); blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification

MMP-13 Inhibitor – 1 mg

Brand:
Cayman
CAS:
544678-85-5
Storage:
-20
UN-No:
Non-Hazardous - /

MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC50 value of 8 nM.{32009,32010} MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs.{32009,32010} MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.{32011}  

 

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Description

A pyrimidine dicarboxamide that selectively inhibits MMP-13 (IC50 = 8 nM); blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification

Formal name: N4,N6-bis[(4-fluoro-3-methylphenyl)methyl]-4,6-pyrimidinedicarboxamide

Synonyms:  4,6-Pyrimidinedicarboxamide|Collagenase-3 Inhibitor|Matrix Metalloproteinase-13 Inhibitor

Molecular weight: 410.4

CAS: 544678-85-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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