A sulfonamide antibiotic; acts synergistically with trimethoprim against a variety of bacteria in vitro

Sulfamoxole – 250 mg

Brand:
Cayman
CAS:
729-99-7
Storage:
-20
UN-No:
Non-Hazardous - /

Sulfamoxole is a sulfonamide antibiotic.{45554} It is inactive or weakly active against bacteria when used alone but acts synergistically with trimethoprim (Item No. 16473) against a variety of bacteria in vitro, including strains of S. pyogenes, E. coli, and P. vulgaris when used at concentrations of 1.95-7.8, 0.12-1.95, and 0.48-0.97 µg/ml, respectively. Sulfamoxole, in combination with trimethoprim, is effective in mouse models of E. coli or P. vulgaris infection. It inhibits P. carinii recombinant dihydropteroate synthase (DHPS), an enzyme required for the biosynthesis of folate, with an IC50 value of 0.089 µM.{38582}  

 

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Description

A sulfonamide antibiotic; acts synergistically with trimethoprim against a variety of bacteria in vitro, including strains of S. pyogenes, E. coli, and P. vulgaris when used at concentrations of 1.95-7.8, 0.12-1.95, and 0.48-0.97 µg/ml, respectively; effective in mouse models of E. coli or P. vulgaris infection when used in combination with trimethoprim; inhibits P. carinii recombinant DHPS (IC50 = 0.089 µM)

Formal name: 4-amino-N-(4,5-dimethyl-2-oxazolyl)-benzenesulfonamide

Synonyms:  NSC 683535

Molecular weight: 267.3

CAS: 729-99-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Sulfonamides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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