Blocks Tie2 kinase activity (Ki = 1.3 µM)

Tie2 Inhibitor 7 – 1 mg

Brand:
Cayman
CAS:
1020412-97-8
Storage:
-20
UN-No:
Non-Hazardous - /

Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.{31456}. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM.{31456} This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.{31456}  

 

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Description

Blocks Tie2 kinase activity (Ki = 1.3 µM), inhibiting angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling (IC50 = 0.3 µM); prevents endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization

Formal name: 5-[4-[[[2-[[(1S)-1-cyclohexylethyl]amino]-2-oxoethyl][(4-methylphenoxy)carbonyl]amino]methyl]phenyl]-3-pyridinecarboxylic acid

Synonyms: 

Molecular weight: 529.6

CAS: 1020412-97-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Signaling

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