A degradation product of tryptophan upon exposure to visible light that activates the AhR (Kd = 70 pM) and is a substrate for CYP1A1

6-Formylindolo[3,2-b]carbazole – 1 mg

Brand:
Cayman
CAS:
172922-91-7
Storage:
-20
UN-No:
Non-Hazardous - /

6-Formylindolo[3,2-b]carbazole (FICZ) is a degradation product of tryptophan upon exposure to visible light that activates the aryl hydrocarbon receptor (AhR; Kd = 70 pM).{31887} This endogenous AhR ligand is also a good substrate for cytochromes P450 (CYP) 1A1, 1A2, and 1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively).{31888} When activated by either environmental toxins or endogenous ligands, the AhR induces detoxifying enzymes and modulates immune cell differentiation. FICZ has been used to study the immunomodulatory and host defense mechanisms of AhR signaling pathways.{27028}  

 

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Description

A degradation product of tryptophan upon exposure to visible light that activates the AhR (Kd = 70 pM) and is a substrate for CYP1A1, CYP1A2, and CYP1B1 (Kis = 15.4, 3.9, and 13.3 µM, respectively); used to study the immunomodulatory and host defense mechanisms of AhR signaling pathways

Formal name: 5,11-dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde

Synonyms:  FICZ

Molecular weight: 284.3

CAS: 172922-91-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Immunology & Inflammation||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing

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