A fungal metabolite with diverse biological activities; inhibits the growth of T lymphoma cells in a concentration-dependent manner; toxic to mosquito (C. pipiens) larvae (LC50 = 3.0 μg/ml); inhibits P-gp activity in vitro (IC50 = 4.7 μM)

Cyclosporin B – 1 mg

Brand:
Cayman
CAS:
63775-95-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclosporin B is a minor cyclopeptide metabolite produced by T. polysporum and other deuteromycota with diverse biological activities.{42099} It inhibits the growth of T lymphoma cells in a concentration-dependent manner.{42100} It is toxic to mosquito (C. pipiens) larvae (LC50 = 3.0 μg/ml).{42101} Cyclosporin B also inhibits P-glycoprotein (P-gp) activity in vitro with an IC50 value of 4.7 μM.{42102}  

 

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Description

A fungal metabolite with diverse biological activities; inhibits the growth of T lymphoma cells in a concentration-dependent manner; toxic to mosquito (C. pipiens) larvae (LC50 = 3.0 μg/ml); inhibits P-gp activity in vitro (IC50 = 4.7 μM) ,,

Formal name: 7-L-alanine-cyclosporin A

Synonyms:  Antibiotic S 7481F2

Molecular weight: 1,188.60

CAS: 63775-95-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation|Adaptive Immunity

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