An inhibitor of glucosylceramide synthase

N-(n-Butyl)deoxygalactonojirimycin – 1 mg

Brand:
Cayman
CAS:
141206-42-0
Storage:
-20
UN-No:
Non-Hazardous - /

N-(n-Butyl)deoxygalactonojirimycin (NB-DGJ) is an inhibitor of the glycolipid biosynthesis enzyme glucosylceramide synthase and the glycolipid catabolic enzymes glucocerebrosidase (GBA) and β-glucosidase 2 (GBA2).{31624,49490,49491,49492,50926} It also inhibits acid α-glucosidase, sucrase, maltase, and lactase.{49492} NB-DGJ (0.5-500 µM) reduces glycolipid levels in HL-60 and WEHI-3B cells.{31624} It decreases brain ganglioside levels in a Glb1-/- neonatal mouse model of GM1 gangliosidosis when administered intraperitoneally at doses of 600 and 1,200 mg/kg four times per day for three days.{31622} NB-DGJ (1-1,200 mg/kg per day for 35 days) increases testicular glucosylceramide levels in mice.{49490} NB-DGJ induces abnormal spermatid and acrosome formation, as well as reduces motility, in isolated mouse epididymal sperm when administered at doses of 15, 25, and 50 mg/kg per day.{50926} It also induces infertility, an effect that is reversed by withdrawal, in the same model.  

 

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An inhibitor of glucosylceramide synthase, GBA, GBA2, acid α-glucosidase, sucrase, maltase, and lactase; reduces glycolipid levels in HL-60 and WEHI-3B cells from 0.5-500 µM; decreases brain ganglioside levels in a Glb1-/-neonatal mouse model of GM1 gangliosidosis at 600 and 1,200 mg/kg four times per day for three days; increases testicular glucosylceramide levels in mice from 1-1,200 mg/kg per day for 35 days; induces abnormal spermatid and acrosome formation, as well as reduces motility, in isolated mouse epididymal sperm at 15, 25, and 50 mg/kg per day; induces infertility, an effect that is reversed by withdrawal, in the same model

Formal name: 1-butyl-2R-(hydroxymethyl)-3S,4R,5S-piperidinetriol

Synonyms:  Lucerastat|NBDGJ

Molecular weight: 219.3

CAS: 141206-42-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Lipid Biochemistry|Sphingolipids

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