An inhibitor of PI3Kα that is selective for p110α in vitro (IC50 = 15 nM for p110α vs. >1 µM for other isoforms

INK1117 – 5 mg

Brand:
Cayman
CAS:
1268454-23-4
Storage:
-20
UN-No:
Non-Hazardous - /

INK1117 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC50 = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR) and in cells when used at 1 µM.{31648,31649} It blocks signaling to Akt and inhibits growth of cancer cells harboring wild-type or mutated p110α.{31648} INK1117 does not interfere with B cell proliferation or NK cell maturation and survival.{31648,31649}  

 

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Description

An inhibitor of PI3Kα that is selective for p110α in vitro (IC50 = 15 nM for p110α vs. >1 µM for other isoforms, as well as for mTOR) and in cells when used at 1 µM

Formal name: [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone

Synonyms:  MLN1117|TAK-117

Molecular weight: 363.4

CAS: 1268454-23-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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