A selective JAK3 inhibitor (Ki = 2.5 nM; IC50 = 50-170 nM); reduces proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity

VX-509 – 5 mg

Brand:
Cayman
CAS:
944842-54-0
Storage:
-20
UN-No:
Non-Hazardous - /

VX-509 is a selective inhibitor of Janus kinase 3 (JAK3) with a Ki value of 2.5 nM in enzyme assays and an IC50 value of 50-170 nM in cellular assays dependent on JAK3 activity with no measurable activity against other JAK isotypes.{31666} At 10-100 mg/kg, it has been shown to dose dependently reduce proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity.{31666}  

 

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Description

A selective JAK3 inhibitor (Ki = 2.5 nM; IC50 = 50-170 nM); reduces proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity

Formal name: (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-N-(2,2,2-trifluoroethyl)-butanamide

Synonyms:  Decernotinib|VRT-831509

Molecular weight: 392.4

CAS: 944842-54-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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