An agonist of RORγt

SR 0987 – 10 mg

Brand:
Cayman
CAS:
303126-97-8
Storage:
-20
UN-No:
Non-Hazardous - /

SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM.{31062} Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA (Item No. 10008014) and ionomycin (Item No. 10004974), increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged.{31062} Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.{31062}  

 

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Description

An agonist of RORγt, inducing reporter gene expression with an EC50 value of ~800 nM; increases expression of IL-17, while decreasing expression of PD-1, in a variety of T cells

Formal name: 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide

Synonyms: 

Molecular weight: 397.7

CAS: 303126-97-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Immunology & Inflammation|Adaptive Immunity

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