Description
A sesquiterpene γ-lactone; inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively); reduces tumor growth in an SCC-4 mouse xenograft model at 40 µg/g; reduces protein levels of NLRP3, caspase-1, IL-1β, and IL-18 induced by cholesterol crystals in LPS-primed mouse peritoneal macrophages at 50 nM; a selective inhibitor of the NLRP3 inflammasome over the NLRP1, AIM2, and NLRC4 inflammasomes when used at 50 nM; decreases plasma levels of IL-1β, oxidized LDL autoantibodies, total cholesterol, and triglycerides, and reduces the size of atherosclerotic lesions in the aorta of mice fed a high-fat diet at 2.5 ng/g
Formal name: (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
Synonyms:
Molecular weight: 246.3
CAS: 84692-91-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Innate Immunity
