An AMPK activator at a concentration of 150 µM in platelets; inhibits thrombin-

YLF-466D – 10 mg

Brand:
Cayman
CAS:
1273323-67-3
Storage:
-20
UN-No:
Non-Hazardous - /

YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis.{40039} YLF-466D activates AMPK at a concentration of 150 µM in platelets. It inhibits platelet aggregation induced by thrombin, ADP, and collagen (IC50s = 84, 55, and 87 µM, respectively) and inhibits aggregation of whole blood. YLF-466D leads to dose-dependent glucose uptake in L6 myotubes and, at a dose of 150 mg/kg, improves glucose tolerance in two mouse models of diabetes.{40040,40038}  

 

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Description

An AMPK activator at a concentration of 150 µM in platelets; inhibits thrombin-, ADP-, and collagen-induced platelet aggregation (IC50s = 84, 55, and 87 µM, respectively); inhibits whole blood aggregation; improves glucose tolerance in mouse models of diabetes

Formal name: 3-[[(3E)-3-[(4-chlorophenyl)phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-1-yl]methyl]-benzoic acid

Synonyms: 

Molecular weight: 465.9

CAS: 1273323-67-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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