A mixture of macrotetralide antibiotics that act as ionophores

Nonactin, Monactin, and Dinactin Mixture – 25 mg

Brand:
Cayman
CAS:
6833-84-7
Storage:
-20
UN-No:
Non-Hazardous - /

Nonactin, monactin, and dinactin mixture is a macrotetralide antibiotic.{46582} This product is a mixture of the macrotetralide antibiotic homologs nonactin, monactin (Item No. 25742), and dinactin (Item No. 20752) that all act as ionophores for monovalent cations.{32001,32000,32002,43436,43437,32289} Nonactin is a mitochondrial membrane uncoupler and an inhibitor of adenine nucleotide translocase (ANT; IC50s = 4.4, 3.3, 4.7, and 3.3 µM for recombinant human ANT1-4, respectively).{46583,46584} It selectively induces apoptosis in cancer cells and induces tumor regression in mouse xenograft models expressing mutant β-catenin over cancer cells and xenografts expressing wild-type β-catenin.{46583} Monactin induces swelling of rat liver mitochondria in medium containing either potassium or sodium, stimulates respiration, and uncouples oxidative phosphorylation.{43440} It also inhibits Wnt signaling via inhibition of TCF-β-catenin transcriptional activity.{43441} Dinactin inhibits T cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.{32291}  

 

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Description

A mixture of macrotetralide antibiotics that act as ionophores

Formal name: (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone

Synonyms: 

Molecular weight: 736.9

CAS: 6833-84-7

Purity: ≥95% (mixture of homologues)

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Antibiotics|Macrolides||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation|Adaptive Immunity

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