A broad-spectrum fluorinated antibiotic; active against human clinical isolates of enteric bacteria (MIC50s = 6.3-12.5 µg/ml); active against clinical isolates of bovine and porcine respiratory tract pathogens (MIC50s = 0.25-4 µg/ml); inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli at 1 mM

Florfenicol – 500 mg

Brand:
Cayman
CAS:
73231-34-2
Storage:
-20
UN-No:
Non-Hazardous - /

Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol (Item No. 21357).{53126} It is active against human clinical isolates of enteric bacteria, including E. coli, Klebsiella, Enterobacter, Citrobacter, P. mirabilis, and Salmonella (MIC50s = 6.3-12.5 µg/ml).{53127} Florfenicol is also active against clinical isolates of various bovine and porcine respiratory tract pathogens, including P. multocida, A. pleuropneumoniae, and B. bronchiseptica (MIC50s = 0.25-4 µg/ml).{53128} It inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli when used at a concentration of 1 mM.{53126} Formulations containing florfenicol have been used in the treatment of infectious respiratory disease in cattle.  

 

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Description

A broad-spectrum fluorinated antibiotic; active against human clinical isolates of enteric bacteria (MIC50s = 6.3-12.5 µg/ml); active against clinical isolates of bovine and porcine respiratory tract pathogens (MIC50s = 0.25-4 µg/ml); inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli at 1 mM

Formal name: 2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]-acetamide

Synonyms:  SCH 25298

Molecular weight: 358.2

CAS: 73231-34-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses

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