An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of MMP-9; profoundly increases the expression of p53 by increasing protein stability in cancer cells and inhibits signaling through STAT3

Ascochlorin – 2.5 mg

Brand:
Cayman
CAS:
26166-39-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells.{31070,31069} It suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of matrix metalloproteinase-9.{31067} At 2 µM, ascochlorin profoundly increases the expression of p53 by increasing protein stability in cancer cells, and, at 50 µm, it inhibits signaling through STAT3.{31068,31066} Ascochlorin also binds and inhibits the mitochondrial cytochrome bc1 complex, blocking reduction of cytochrome b by ubiquinone.{31065}  

 

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Description

An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of MMP-9; profoundly increases the expression of p53 by increasing protein stability in cancer cells and inhibits signaling through STAT3

Formal name: 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,4E)-3-methyl-5-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]-2,4-pentadien-1-yl]-benzaldehyde

Synonyms:  Antibiotic LL-Z1272γ|Ilicicolin D|NSC 287492

Molecular weight: 404.9

CAS: 26166-39-2

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Cancer|Transcription Factors|STATs||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Infectious Disease|Viral Diseases

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