A dual inhibitor of mTOR and DNA-PK (IC50s = 22 and 15 nM

CC-115 – 1 mg

Brand:
Cayman
CAS:
1228013-15-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC50s = 22 and 15 nM, respectively).{34733} CC-115 reduces PC3 cancer cell growth in vitro (IC50 = 138 nM) and exhibits effective reduction of murine PC3 tumor xenografts (mEC50 = 1 mg/kg). In a Phase I clinical trial, formulations containing CC-115 reduced lymph node sizes in almost all patients with chronic lymphocytic leukemia (CLL) that also have ataxia telangiectasia mutated (ATM) kinase deletions.{34734}  

 

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Description

A dual inhibitor of mTOR and DNA-PK (IC50s = 22 and 15 nM, respectively); reduces PC3 cancer cell growth in vitro (IC50 = 138 nM); exhibits effective reduction of murine PC3 tumor xenografts (mEC50 = 1 mg/kg)

Formal name: 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-pyrazino[2,3-b]pyrazin-2(1H)-one

Synonyms: 

Molecular weight: 336.4

CAS: 1228013-15-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|DNA-PK||Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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