A potent PPARα agonist (EC50 = 10 nM in a transactivation assay using HEK293 cells); selective for PPARα over PPARγ (EC50 = 4

BMS 687453 – 1 mg

Brand:
Cayman
CAS:
1000998-59-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

BMS 687453 is a potent agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 10 nM in a transactivation assay using HEK293 cells).{43668} It is selective for PPARα over PPARγ (EC50 = 4,100 nM) as well as over a panel of human nuclear hormone receptors, including PPARδ, LXR, and RXR (EC50s = >25 μM). BMS 687453 (10-100 mg/kg) reduces plasma triglyceride levels and increases HDL levels in human ApoA1 transgenic mice. It also reduces serum triglyceride and LDL levels in hamsters fed a high-fat diet.{31212}  

 

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Description

A potent PPARα agonist (EC50 = 10 nM in a transactivation assay using HEK293 cells); selective for PPARα over PPARγ (EC50 = 4,100 nM) as well as over a panel of human nuclear hormone receptors (EC50s = >25 μM); reduces plasma triglyceride levels and increases HDL levels in human ApoA1 transgenic mice from 10-100 mg/kg; reduces serum triglyceride and LDL levels in hamsters fed a high-fat diet,

Formal name: N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-glycine

Synonyms: 

Molecular weight: 444.9

CAS: 1000998-59-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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