An inhibitor of the FAFHA hydrolases AIG1 and ADTRP (IC50s = 0.57 and 8.5 µM

JJH260 – 5 mg

Brand:
Cayman
CAS:
1831135-30-8
Storage:
-20
UN-No:
Non-Hazardous - /

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA (Item No. 17037) with an IC50 value of 0.57 µM.{30849} JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 µM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2.{30849} JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.{30849}  

 

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Description

An inhibitor of the FAFHA hydrolases AIG1 and ADTRP (IC50s = 0.57 and 8.5 µM, respectively); also inhibits ABHD6, LYPLA1, and LYPLA2; inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells

Formal name: 4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylic acid, 7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester

Synonyms: 

Molecular weight: 568.1

CAS: 1831135-30-8

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Fatty Acids

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