An irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM); selectively cytotoxic to cancer cell lines that express CYP4F11 over those that don't (IC50s = 22-116 and >10

SW203668 (trifluoroacetate salt) – 1 mg

Brand:
Cayman
CAS:
2117405-48-6
Storage:
-20
UN-No:
Non-Hazardous - /

SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM).{30821} It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively.  

 

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Description

An irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM); selectively cytotoxic to cancer cell lines that express CYP4F11 over those that don’t (IC50s = 22-116 and >10,000 nM, respectively); reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and NOD-SCID mouse xenograft models at 20 and 6 mg/kg, respectively

Formal name: 4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide, trifluoroacetate salt

Synonyms: 

Molecular weight: 503.5

CAS: 2117405-48-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Cancer||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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