A pan-PPAR agonist (EC50s = 4.0

Bavachinin – 10 mg

Brand:
Cayman
CAS:
19879-30-2
Storage:
-20
UN-No:
Non-Hazardous - /

Bavachinin is a natural flavanone first isolated from seeds of P. corylifolia. It is a pan-PPAR agonist (EC50s = 4.0, 8.1, and 0.74 µM for PPARα, β/δ, and γ, respectively).{30858} Bavachinin has synergistic effects when combined with thiazolidinediones or fibrates. It lowers glucose and triacylglycerol levels in db/db mice without inducing weight gain or hepatotoxicity.{30858} Bavachinin also has actions that block allergic inflammation, angiogenesis, and Aβ42 aggregation in vitro.{31775,33151,33152}  

 

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Description

A pan-PPAR agonist (EC50s = 4.0, 8.1, and 0.74 µM for PPARα, β/δ, and γ, respectively); has synergistic effects when combined with thiazolidinediones or fibrates; lowers glucose and triacylglycerol levels in db/db mice

Formal name: (2S)-2,3-dihydro-2-(4-hydroxyphenyl)-7-methoxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one

Synonyms:  7-O-Methylbavachin

Molecular weight: 338.4

CAS: 19879-30-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Metabolism||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Allergy||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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