A water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 value of 0.47 µM; has broad anticancer activity in mice when administered orally

CBL0137 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1197397-89-9
Storage:
-20
UN-No:
Non-Hazardous - /

Curaxins are small molecules that simultaneously activate p53 and inhibit NF-κB without causing detectable genotoxicity.{30977} CBL0137 is a water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 value of 0.47 µM.{30977} It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death.{30977} CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Item No. 11690) in preclinical models of pancreatic cancer.{30977,30976}  

 

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Description

A water soluble and metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 value of 0.47 µM; has broad anticancer activity in mice when administered orally

Formal name: 1,1′-[9-[2-[(1-methylethyl)imino]ethyl]-9H-carbazole-3,6-diyl]bis-ethanone, monohydrochloride

Synonyms:  CBLC137|Curaxin 137

Molecular weight: 372.9

CAS: 1197397-89-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cancer|Transcription Factors|p53||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling

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