A selective

VU0255035 – 50 mg

Brand:
Cayman
CAS:
1135243-19-4
Storage:
-20
UN-No:
Non-Hazardous - /

VU0255035 is a competitive, orthosteric antagonist of the muscarinic M1 receptor (IC50 = 130 nM).{30840,30841} It displays at least 75-fold selectivity for M1 over other muscarinic receptors, as well as a panel of receptors, ion channels, and transporters.{30840,30841} VU0255035 is effective in cells and in vivo and brain penetrating, blocking pilocarpine-induced seizures without disrupting contextual fear conditioning in mice.{30840,30841} VU0255035 is used to examine the role of the M1 receptor in diverse situations.{25277,30842,30839}  

 

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Description

A selective, competitive orthosteric antagonist of the muscarinic M1 receptor (IC50 = 130 nM); is effective in cells and in vivo and brain penetrating, blocking pilocarpine-induced seizures without disrupting contextual fear conditioning in mice

Formal name: N-[3-oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide

Synonyms:  ML-012

Molecular weight: 432.5

CAS: 1135243-19-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience||Research Area|Neuroscience|Seizure Disorders

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