A small molecule that induces non-apoptotic cell death in an ACC1-dependent manner; HT-1080 cells lacking ACC1 exhibit 5-fold resistance to CIL56 treatment; induces accumulation of long-chain saturated

CIL56 – 1 mg

Brand:
Cayman
CAS:
300802-28-2
Storage:
-20
UN-No:
Non-Hazardous - /

CIL56 is a small molecule that induces non-apoptotic cell death in a manner dependent on acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis.{39187} HT-1080 cells lacking ACC1 exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death. CIL56 (6.5 μM) induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.  

 

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Description

A small molecule that induces non-apoptotic cell death in an ACC1-dependent manner; HT-1080 cells lacking ACC1 exhibit 5-fold resistance to CIL56 treatment; induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro at 6.5 μM

Formal name: 2,7-bis(1-piperidinylsulfonyl)-9H-fluoren-9-one, oxime

Synonyms: 

Molecular weight: 489.6

CAS: 300802-28-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area

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