A natural product; inhibits recombinant and HCT116 and HT29 colon cancer cell-derived ODC in a dose-dependent manner; suppresses anchorage-independent growth

Herbacetin – 1 mg

Brand:
Cayman
CAS:
527-95-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Herbacetin is a natural product that acts as a selective inhibitor of ornithine decarboxylase (ODC).{39081} It inhibits recombinant and HCT116 and HT29 colon cancer cell-derived ODC in a dose-dependent manner while having no effect on 13 tested kinases or S-adenosylmethionine decarboxylase in vitro. Herbacetin suppresses anchorage-independent growth, activation of activator protein-1 (AP-1), a MAP kinase transcription factor, and phosphorylation of ERK1/2 and p90RSK in vitro. It suppresses HCT116 xenograft tumor growth in mice without significant body weight loss when administered i.p. or orally. Herbacetin also inhibits acetylcholinesterase (AChE; IC50 = 1.37 μM) in vitro.{39082}  

 

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Description

A natural product; inhibits recombinant and HCT116 and HT29 colon cancer cell-derived ODC in a dose-dependent manner; suppresses anchorage-independent growth, activation of AP-1, and phosphorylation of ERK1/2 and p90RSK in vitro; suppresses HCT116 xenograft tumor growth in mice; inhibits AChE (IC50 = 1.37 μM) in vitro ,

Formal name: 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  3,5,7,8,4′-Pentahydroxyflavone|8-hydroxy Kaempferol|Isoarticulatidin

Molecular weight: 302.2

CAS: 527-95-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Cancer|Transcription Factors||Research Area|Neuroscience

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