Description
An inhibitor of Atox1 and CCS; binds to purified Atox1 and CCS (Kds = 6.8 and 8.2 μM, respectively); inhibits the interaction between Atox1 and domain 4 of ATP7B in the presence of zinc in a FRET-based assay at 100 μM; increases copper and ROS levels and decreases COX activity and lipid biosynthesis in H1299 cells at 10 μM; inhibits the proliferation of H1299, K562, MDA-MB-231, and 212LN cancer cells, but not PIG1, HDF, HaCaT, or MCF-10A cells, in a concentration-dependent manner; reduces tumor growth in an H1299 mouse xenograft model at 100 mg/kg per day
Formal name: 3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide
Synonyms:
Molecular weight: 424.3
CAS: 497061-48-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents||Research Area|Cancer||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
