A competitive inhibitor of PFKFB3 (IC50 = 23 µM) that causes a rapid reduction in F2

3PO – 10 mg

Brand:
Cayman
CAS:
18550-98-6
Storage:
-20
UN-No:
Non-Hazardous - /

3PO is a competitive inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 3 (PFKFB3; IC50 = 23 µM) that causes a rapid reduction in fructose-2,6-bisphosphate (F2,6BP), glucose uptake, and lactate secretion.{31403,30752} This is followed by a reduction in the steady-state concentration of ATP and NADH, resulting in cell cycle arrest in Jurkat T cell leukemia cells.{31403,30752} 3PO is selectively cytostatic to ras-transformed bronchial epithelial cells relative to normal bronchial epithelial cells.{31403} 3PO markedly reduces intracellular F2,6BP, glucose uptake, and growth of established tumors in mice.{31403} It also blocks angiogenesis, reducing vessel sprouting in endothelial cell spheroids, zebrafish embryos, and the postnatal mouse retina by inhibiting endothelial cell proliferation and migration.{31404}  

 

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Description

A competitive inhibitor of PFKFB3 (IC50 = 23 µM) that causes a rapid reduction in F2,6BP, glucose uptake, and lactate secretion, resulting in cell cycle arrest in Jurkat cells; markedly reduces intracellular F2,6BP, glucose uptake, and growth of established tumors in mice; also blocks angiogenesis

Formal name: 3-(3-pyridinyl)-1-(4-pyridinyl)-2E-propen-1-one

Synonyms: 

Molecular weight: 210.2

CAS: 18550-98-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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