An orally available

Tanomastat – 1 mg

Brand:
Cayman
CAS:
179545-77-8
Storage:
-20
UN-No:
Non-Hazardous - /

Tanomastat is an orally available, non-peptidic inhibitor of matrix metalloproteinase-2 (MMP-2), MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively).{23056} It is active in various animal models of tumor metastasis and has been used in a phase III clinical trial in pancreatic, SCLC, NSCLC, and ovarian cancer patients.{31162,25117}  

 

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Description

An orally available, non-peptidic inhibitor of MMP-2, MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively); active in various animal models of tumor metastasis and has been used in a phase III clinical trial in pancreatic, SCLC, NSCLC, and ovarian cancer patients

Formal name: 4′-chloro-γ-oxo-αS-[(phenylthio)methyl]-[1,1′-biphenyl]-4-butanoic acid

Synonyms:  BAY 12-9566

Molecular weight: 410.9

CAS: 179545-77-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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