A selective

Calyculin A – 10 µg

Brand:
Cayman
CAS:
101932-71-2
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Calyculin A is a natural, cell-permeable inhibitor of the serine-threonine protein phosphatases (PP) PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively).{32313,21678,32314} It is without significant effect against PP2B, PP2C, and PP4.{21678} Through its effects on PP1 and PP2A, calyculin A has been shown to either promote or inhibit cancer cell growth in tumor cell lines and animal models.{32312,18481}  

 

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Description

A selective, cell-permeable inhibitor of PP1 and PP2A (IC50s = 0.3-0.7 and 0.5-1 nM, respectively)

Formal name: N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propen-1-yl]-2-oxazolyl]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide

Synonyms:  (-)-Calyculin A

Molecular weight: 1,009.20

CAS: 101932-71-2

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer||Research Area|Cell Biology|Cell Signaling

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