A phytochemical that inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS

Nimbolide – 25 mg

Brand:
Cayman
CAS:
25990-37-8
Storage:
-20
UN-No:
Non-Hazardous - /

Nimbolide is a terpenoid lactone first isolated from A. indica (Neem tree) that demonstrates antimalarial and anticancer effects in experimental models.{30598} It inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS, reducing PI3K/Akt/mTOR and ERK signaling, and upregulating the pro-apoptotic proteins Bax, caspase-3, and PARP.{30598}  

 

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Description

A phytochemical that inhibits pancreatic cancer cell growth and metastasis by inducing the excessive generation of ROS, reducing PI3K/Akt/mTOR and ERK signaling, and up-regulating pro-apoptotic proteins

Formal name: 8-(3-furanyl)-2aR,5aR,6S,6aR,8R,9,9aR,10aS,10bR,10cR-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-2H,5H-cyclopenta[d’]naphtho[1,8-bc:2,3-b’]difuran-6-acetic acid, methyl ester

Synonyms:  NSC 309909

Molecular weight: 466.5

CAS: 25990-37-8

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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