A pan-NADPH oxidase inhibitor; pre-incubation of rat smooth muscle cells abolishes PDGF induced chemotaxis (IC50 = 10 µM); increases glucose-stimulated insulin secretion of rat pancreatic islets by 70%; reduces production of ROS in vitro and in vivo; is neuroprotective in murine stroke models

VAS2870 – 25 mg

Brand:
Cayman
CAS:
722456-31-7
Storage:
-20
UN-No:
Non-Hazardous - /

VAS2870 is a selective inhibitor of the NADPH oxidases.{34568,34569,34570,34593} Pre-incubation of rat vascular smooth muscle cells with VAS2870 abolishes platelet-derived growth factor-dependent chemotaxis without affecting cell cycle progression (IC50 = 10 µM).{34568} At low (2.8 mM), but not high (16.7 mM), concentrations of glucose, treatment with VAS2870 (20 µM) increases glucose-stimulated insulin secretion of rat pancreatic islets by 70%.{34575} It significantly reduces production of reactive oxygen species in mouse brain, rat vascular smooth muscle culture, and human umbilical vein endothelial cells.{34568,34571,34572} Treatment with VAS2870 pre- or post-ischemia is neuroprotective in mouse brain.{34571} VAS2870 inhibits vasculogenesis of mouse embryonic stem cell cultures and inhibits cell proliferation of rat hepatoma cells.{34573,34574}  

 

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Description

A pan-NADPH oxidase inhibitor; pre-incubation of rat smooth muscle cells abolishes PDGF induced chemotaxis (IC50 = 10 µM); increases glucose-stimulated insulin secretion of rat pancreatic islets by 70%; reduces production of ROS in vitro and in vivo; is neuroprotective in murine stroke models

Formal name: 7-(2-benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine

Synonyms: 

Molecular weight: 360.4

CAS: 722456-31-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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