An inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 µM in isolated human plasma); decreases ANIT-induced increases in the expression of the profibrogenic genes Timp1 and Col1a1

Tranexamic Acid – 250 g

Brand:
Cayman
CAS:
1197-18-8
Storage:
22
UN-No:
Non-Hazardous - /

Tranexamic acid is an inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 µM in isolated human plasma).{31118} It decreases α-naphthylisothiocyanate (ANIT)-induced increases in the expression of the profibrogenic genes Timp1 and Col1a1, but not Itgb6, Tgfβ1, or Tgfβ2, and reduces protein levels of cytokeratin 19 (CK19) and type I collagen in the liver after 28 days in a mouse model of chronic bile duct injury.{45512}  

 

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Description

An inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 µM in isolated human plasma); decreases ANIT-induced increases in the expression of the profibrogenic genes Timp1 and Col1a1, but not Itgb6, Tgfβ1, or Tgfβ2, and reduces protein levels of CK19 and type I collagen in the liver after 28 days in a mouse model of chronic bile duct injury

Formal name: trans-4-(aminomethyl)-cyclohexanecarboxylic acid

Synonyms:  AMCA|TXA

Molecular weight: 157.2

CAS: 1197-18-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism

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