An NSAID that inhibits both COX-1 (IC50 = 113 µM) and COX-2 (IC50s = 8.2 and 134 µM for human whole blood assay and human-modified whole blood assays

Diflunisal – 50 g

Brand:
Cayman
CAS:
22494-42-4
Storage:
22
UN-No:
Non-Hazardous - /

Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) that inhibits both COX-1 (IC50 = 113 µM) and COX-2 (IC50s = 8.2 and 134 µM for human whole blood assay and human-modified whole blood assays, respectively).{8427} Peak plasma levels are achieved within two hours, with little metabolism before excretion in the urine.{31037} The terminal plasma half-life is approximately eight hours.{31037}  

 

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Description

An NSAID that inhibits both COX-1 (IC50 = 113 µM) and COX-2 (IC50s = 8.2 and 134 µM for human whole blood assay and human-modified whole blood assays, respectively)

Formal name: 2′,4′-difluoro-4-hydroxy-[1,1′-biphenyl]-3-carboxylic acid

Synonyms:  5-(2,4-Difluorophenyl)salicylic Acid|MK-647

Molecular weight: 250.2

CAS: 22494-42-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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