A selective

MLCK Inhibitor Peptide 18 – 1 mg

Brand:
Cayman
CAS:
224579-74-2
Storage:
-20
UN-No:
Non-Hazardous - /

MLCK inhibitor peptide 18 is a cell-permeable inhibitor of myosin light chain kinase (MLCK; IC50 = 50 nM) with 4,000-fold selectivity for MLCK over CaM kinase II and PKA.{31132,31133} It prevents defects in transepithelial barrier resistance induced by bacteria or TNF-α plus IFN-γ.{31133} MLCK inhibitor peptide 18 prevents sperm chromatin-induced cortical reorganization in mouse oocytes and decreases phagocytosis of C3bi-opsonized and non-opsonized myelin by primary mouse microglia.{31130,31131}  

 

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Description

A selective, cell-permeable inhibitor of MLCK (IC50 = 50 nM)

Formal name: L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide

Synonyms:  Myosin Light Chain Kinase Inhibitor Peptide 18

Molecular weight: 1,324.60

CAS: 224579-74-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis

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