A selective Chk2 inhibitor (IC50 = 3 nM); potentiates the cytotoxicity of the PARP inhibitors

CCT241533 (hydrochloride) – 500 µg

Brand:
Cayman
CAS:
1431697-96-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

CCT241533 is a selective inhibitor of checkpoint kinase 2 (Chk2; IC50 = 3 nM).{34692} In human cancer cell lines, CCT241533 blocks Chk2 activity and potentiates the cytotoxicity of the PARP inhibitors, rucaparib, AG-1447; (Item No. 15643) and olaparib (Item No. 10621).{34691}  

 

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Description

A selective Chk2 inhibitor (IC50 = 3 nM); potentiates the cytotoxicity of the PARP inhibitors, rucaparib and olaparib,

Formal name: (3R,4S)-rel-4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol, monohydrochloride

Synonyms: 

Molecular weight: 479

CAS: 1431697-96-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Checkpoint Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling

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