A potent inhibitor of Aurora A (IC50 = 0.064 nM) that less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM

MK-5108 – 5 mg

Brand:
Cayman
CAS:
1010085-13-8
Storage:
-20
UN-No:
Non-Hazardous - /

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM).{30910} It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types.{30910,30911} It is effective in vivo, inhibiting the growth of xenograft tumors in mice.{30910}  

 

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Description

A potent inhibitor of Aurora A (IC50 = 0.064 nM) that less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively); blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types; effective in vivo

Formal name: trans-4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-cyclohexanecarboxylic acid

Synonyms:  VX-689

Molecular weight: 461.9

CAS: 1010085-13-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Aurora Signaling

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