A resorcylic acid lactone with antiviral and antiprotozoan activity; used as negative control for MAPKKK inhibitor (5Z)-7-oxo zeaenol (Item No. 17459)

LL-Z 1640-4 – 5 mg

Brand:
Cayman
CAS:
66018-41-5
Storage:
-20
UN-No:
Non-Hazardous - /

LL-Z 1640-4 is a cis-enol resorcylic acid lactone that has been shown to exhibit both antiviral and antiprotozoan activity.{30734} While LL-Z 1640-4 is inactive against JNK/p38 kinase signaling, its companion antibiotic, (5Z)-7-oxo zeaenol (Item No. 17459), has been identified as an irreversible inhibitor of the MAPKKK, TAK1, blocking T cell activation.{30735} Thus, LL-Z 1640-4 is useful as negative control to help dissect the selectivity of this MAPKKK inhibitor.  

 

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Description

A resorcylic acid lactone with antiviral and antiprotozoan activity; used as negative control for MAPKKK inhibitor (5Z)-7-oxo zeaenol (Item No. 17459)

Formal name: 3,4,7,8,9,10-hexahydro-7,8,9,16-tetrahydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one

Synonyms:  (5Z)-Zeaenol|Antibiotic LLZ1640-4

Molecular weight: 364.4

CAS: 66018-41-5

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|Negative Controls||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Infectious Disease|Viral Diseases

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