A selective endothelial lipase inhibitor (IC50 = 237 nM); an oral dose of 30 mg/kg increases HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice

XEN445 – 10 mg

Brand:
Cayman
CAS:
1515856-92-4
Storage:
-20
UN-No:
Non-Hazardous - /

Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50s = 20 and 9.5 µM, respectivley).{31026} An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice.{31026}  

 

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Description

A selective endothelial lipase inhibitor (IC50 = 237 nM); an oral dose of 30 mg/kg increases HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice

Formal name: 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)-benzoic acid

Synonyms: 

Molecular weight: 366.3

CAS: 1515856-92-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Glycerolipid Lipases||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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