A Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1; downregulates the expression of fibrogenic genes

NK 252 – 1 mg

Brand:
Cayman
CAS:
1414963-82-8
Storage:
-20
UN-No:
Non-Hazardous - /

NK 252 is a Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1.{31236} At 1.36 µM, it is reported to activate the NQO1-antioxidant response element in a luciferase reporter gene assay two-fold above background.{31236} NK 252 has been shown to downregulate the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis.{31236}  

 

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Description

A Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1; downregulates the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis

Formal name: N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-N’-(2-pyridinylmethyl)-urea

Synonyms: 

Molecular weight: 285.3

CAS: 1414963-82-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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