An orally available inverse agonist of PPARβ/δ (IC50 = 27 nM)

DG-172 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1361504-77-9
Storage:
-20
UN-No:
Non-Hazardous - /

DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM).{31239} It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells.{31238} Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.{31237}  

 

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Description

An orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM)

Formal name: 2-bromo-αZ-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]-benzeneacetonitrile, dihydrochloride

Synonyms: 

Molecular weight: 455.2

CAS: 1361504-77-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs

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